Evaluation of Antiarthritic Potentials of Methanolic Stem Extract of Tecoma Stans Linn in Wistar Albino Rat

Objective: The present study was designed to investigate the antiarthritic activity of methanolic stem extract of Tecoma stans in wistar albino rats using in vitro albumin denaturation method and in vivo models like complete freunds adjuvant (CFA) induced arthritis and egg albumin induced arthritic models. Acute toxicity studies were carried out and the extract was found to be safe upto 2000 mg/kg bd.wt.The methanolic stem extract of Tecoma stans significantly lowered protein denaturation. The extract showed significant inhibition of paw volume in both complete freunds adjuvant and egg albumin induced arthritis. Upon treatment with the extract the animals gained weight compared to negative control. The presence of active constituents like alkaloids, glycosides steroids and flavonoids in extract might be responsible for its prominent anti-arthritic activity. From the above it is clear that the methanolic extract of Tecoma stans possess anti-arthritic activity.